Hdc-2A-CreERT2

品系全名

C57BL/6Smoc-Hdcem(2A-CreERT2)Smoc

目录号

NM-KI-220044

品系状态

精子冻存

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基因信息

基因名
Hdc

基因曾用名

Hdc-a; Hdc-c; Hdc-e; Hdc-s; AW108189

NCBI ID

15186

MGI ID

96062

Ensembl ID

ENSMUSG00000027360

Pubmed

Hdc

人类同源基因

HDC

品系描述

将2A-CreERT2插入到小鼠Hdc基因终止密码子处。

验证数据

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Fig1. CreERT2 mediated recombination in brain of HdcCreERT2/+; Rosa26tdTomato/+ mouse. 

image.png

Fig2. Detection of tdTomato(red) in various tissues of HdcCreERT2/+; Rosa26tdTomato/+ mouse. 

The tissues that express tdTomato include: brain, spinal cord, lungs, liver, stomach, adrenal glands, kidneys, spleen, reproductive organs, thymus, and pituitary gland. Tissues with minimal tdTomato expression include: small intestine and skin. 

Tissues that do not express tdTomato: heart, eyes, salivary glands, brown adipose tissue, pancreas, large intestine, and muscle. 

In the control group, tdTomato shows very minimal leaky expression in the brain, stomach, adrenal glands, kidneys, spleen, and thymus. (8-weeks old, male) (For more detailed information please contact our technical advisor.) 

发表文献

An H2R-dependent medial septum histaminergic circuit mediates feeding behavior
来源杂志：Current Biology

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