hCD3EDG/hDLL3
品系全名
C57BL/6Smoc-Cd3etm1(hCD3E)Cd3dtm1(hCD3D)Cd3gtm1(hCD3G)Dll3em1(hDLL3) /Smoc
目录号
NM-XA-240036
品系状态
活体
基因信息
基因名
Dll3
品系描述
验证数据
Fig.1 Detection of humanized DLL3 expression in male hCD3EDG/hDLL3 mice by RT-PCR.
Homozygous: one band at 282 bp with primers F2/R2(hDLL3).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of humanized DLL3 expression in female hCD3EDG/hDLL3 mice by RT-PCR.
Homozygous: one band at 282 bp with primers F2/R2(hDLL3).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.3 Detection of mouse Dll3 expression in male hCD3EDG/hDLL3 mice by RT-PCR.
Wild type: one band at 172 bp with primers F1/R1(mDll3).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.4 Detection of mouse Dll3 expression in female hCD3EDG/hDLL3 mice by RT-PCR.
Wild type: one band at 172 bp with primers F1/R1(mDll3).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.5 Detection of mouse Gapdh expression in male hCD3EDG/hDLL3 mice by RT-PCR.
Wild type and homozygous: one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.6 Detection of mouse Gapdh expression in female hCD3EDG/hDLL3 mice by RT-PCR.
Wild type and homozygous: one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.7 Detection of (A) body weight, (B) the weights of different tissues and (C) organ index in hCD3EDG/hDLL3 mice.
Fig.8 Detection of mIgG(A) and mIgM(B) expression in serum by ELISA.
Abbr. HO, homozygous; WT, wild type.
Fig.9 Detection of immune phenotype in (A) peripheral blood and (B) spleen by FACS.
Abbr. HO, homozygous; WT, wild type.
Table 1. Blood routine examination in hCD3EDG/hDLL3 dKI mice (n=3 /group).
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