2210010C04Rik-D23A

Fig 1. The pancreas of a heterozygous female mouse with Rik^D23A/+ mutation. 

Pancreatic tissue from 2-week-old and 23-week-old RikD23A/+ heterozygous female mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes.The scale bar corresponds to 200 µm.

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked

Fig 2. The pancreas of a heterozygous male mouse with Rik^D23A/+ mutation

Pancreatic tissue from 4-week-old and 8-week-old RikD23A/+ heterozygous male mice exhibited a loss of acinar cells, accompanied by infiltration of inflammatory cells, acinar-ductal metaplasia, fat infiltration, and fibrotic changes；The degree of fat infiltration and fibrosis is not significant in 2-week-old mice, and other phenotypes are mild.The scale bar corresponds to 200 µm.

Pathology scores:0 represents within the normal range, 1 represents mild, 2 represents moderate, and 3 represents marked