hF11

通过同源重组，将小鼠F11基因进行人源化修饰。

Fig1. Detection of F11 expression in liver by RT-PCR. 

Wild type: only one band at 364 bp with primers F1/R1(mF11);

Homozygous: only one band at 364 bp with primers F2/R2(hF11); 

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

Fig 2. Detection of hF11 expression in plasma by ELISA (female，RayBiotech, ELH-CoagFXI-1). 

Abbr. HO, homozygous; WT, wild type.

Fig3. Detection of hF11 expression in plasma by ELISA (male，Abcam, ab108834). 

Abbr. HO, homozygous; WT, wild type.

Fig4. Prothrombinogen time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) in hF11 mice. （male, A.  8-10 weeks of age; B. 10-12 weeks of age.)