Lmna-c.C1827T
品系全名
C57BL/6Smoc- Lmnatm1(G609G)Smoc
目录号
NM-KI-200284
品系状态
精子冻存
基因信息
基因名
Lmna
品系描述
将小鼠Lmna基因609位氨基酸由G替换为G（GGC→GGT)），建立该Lmna基因点突变小鼠模型。
*使用本品系发表的文献需注明: Lmna-c.C1827T mice (Cat. NO. NM-KI-200284) were purchased from Shanghai Model Organisms Center, Inc..
疾病预测
早衰
Progeria
Progeria
验证数据
Fig.1 Detection of Lmna expression in colon by RT-PCR.
Homozygous, heterozygous and wild type: one band at 288 bp with primers F1/R1(mLmna) and one band at 123 bp with primers F/R(mGapdh).
Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig.2 The sequencing results are as expected.
Fig.3 Detection of Lmna expression in Lmna-c.C1827T mice by WB. (Red Arrow indicates expected Progerin band)
Abbr. M, marker; WT, wild type; HO, Homozygous; HE, heterozygous; PC, positive control, Hela cells.
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