Cx3cr1-Cre

利用CRISPR基因编辑技术，将iCre替换小鼠Cx3cr1基因的编码区。

Fig. 1 Cre-mediated recombination in the lung of Cx3cr1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary macrophage of Cx3cr1Cre/+; Rosa26tdTomato/+ mouse.

Fig. 2 Cre-mediated recombination in the liver of Cx3cr1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the hepatic kupffer cells  of Cx3cr1Cre/+; Rosa26tdTomato/+ mouse.

Fig. 3 Cre-mediated recombination in the brain of Cx3cr1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the microglial cells of Cx3cr1Cre/+; Rosa26tdTomato/+ mouse.

Fig. 4 Detection of tdTomato(red) in various tissues of Cx3cr1Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, liver, lung, stomach, salivary gland, small intestine, spinal cord, spleen, testis and epididymis, skin and subcutaneous tissue, skeletal muscle and thymus. Tdtomato expression can not be observed in the brown fat, heart, retina, kidney or pancreas. (For more detailed information please contact our technical advisor.)