雄激素脱发疾病模型

疾病简介

雄激素性脱发(androgenetic alopecia,AGA),是一种受遗传因素和雄激素影响的脱发类型,表现为头顶和前额的脱发。男性和女性都可能受到影响,但在男性中更为普遍和显著。雄激素性脱发的特点是头发逐渐变薄,最终导致部分或全部秃顶。目前,有多种治疗方法可以帮助减缓脱发过程或促进头发再生,包括药物治疗、激光治疗和毛发移植等。

疾病模型

南模生物长期致力于自身免疫性疾病相关研究,开发了多种脱发小鼠模型,为相关药物的药效评估和安全性评价提供了强有力的工具。

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After an acclimatization period of 7 days, the dorsal skin area of approximately 2 × 2 cm was depilated for all mice (Day 0).

Control group: Treated with saline; Model group: Treated with testosterone propionate; Treatment group: Treated with testosterone propionate + minoxidil tincture.

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Fig.1 clinical symptoms of androgenetic alopecia mouse model and statistical data analysis, other analysis are on going.

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Fig.2 Representative images of H&E pathological results. Blue arrow means normal hair follicle.

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