细胞系来源的异种移植肿瘤模型(cell line-derived
xenograft,CDX)是将体外培养的人源肿瘤细胞接种至免疫缺陷小鼠体内而构建的模型,其具有建模时间短、重复性好、成本低等特点。作为经典的体内实验方法,CDX
肿瘤模型在肿瘤学研究和抗肿瘤药物研发过程中有着极大的需求。
南模生物目前已建立庞大的 CDX 模型资源库,包含200余种细胞系,覆盖全身各类组织器官,可提供多种有效的人源肿瘤细胞系异体移植药效模型。
我们也可以为您提供肿瘤生长曲线、体重曲线、生化指标、病理检测和 mRNA 、蛋白水平检测等多种药理评估手段,满足您药物药效学评价分析的多种需求。
CDX肿瘤模型案例

Fig. In situ transplantation tumour model based on HepG2-Luc hepatocellular carcinoma cells (host mouse: M-NSG). a. Model tumourigenic curve versus body weight curve; b. Photograph of mouse liver; c. Mouse live imaging image.

Fig. Lung in situ graft tumour model constructed based on the human SHP-77-Luc lung cancer cell line.

Fig. Pancreatic in situ graft tumour model constructed based on the human PANC-1-Luc pancreatic cancer cell line.

Fig. Cervical transplantation in situ tumour model constructed based on the human Hela-Luc cervical cancer cell line.

Fig. In situ graft tumour model of glioma constructed based on the human U87MG glioma cell line.

Fig. In situ transplant tumour model of bladder cancer constructed based on the human RT112-Luc bladder cancer cell line.

Fig. Femoral injection bone metastasis model constructed based on the human MDA-MB-231-Luc breast cancer cell line.
CDX肿瘤药效案例

Fig. Anti-tumour drug efficacy validation experiments using the CDX model of ovarian cancer cell line (SK-OV-3).

Fig. CAR-T cell therapy efficacy validation experiment using lung cancer cell line (A549) CDX model.

Fig. mRNA anti-tumor drug efficacy validation experiments using the CDX model of the B-lymphoblastic leukaemia cell line (Nalm6-Luc).
病人组织来源的异种移植肿瘤模型(patient-derivedxenografts,PDX)是将肿瘤患者的肿瘤组织移植至重症免疫缺陷型小鼠体内而形成的模型。PDX
模型可以较完整地保持患者肿瘤原有的生物学特征、病理分型、分子标志物表达、基因突变类型等,在临床前实验中应用广泛。
南模生物可提供包括肺癌、肝癌、宫颈癌、结直肠癌、脑部肿瘤、前列腺癌、乳腺癌、肾癌、胃癌、胰腺癌等超2000种PDX模型。
肿瘤类型 |
数量 |
膀胱癌 |
15+ |
肺癌 |
150+ |
肝癌 |
400+ |
宫颈癌 |
10+ |
结直肠癌 |
600+ |
卵巢癌 |
200+ |
脑部肿瘤 |
10+ |
肿瘤类型 |
数量 |
前列腺癌 |
15+ |
乳腺癌 |
150+ |
肾癌 |
400+ |
胃癌 |
10+ |
胰腺癌 |
600+ |
子宫肿瘤 |
200+ |
PDX肿瘤模型案例

Fig. Tumorigenic validation and pathological detection of hepatocellular carcinoma PDX tumor models in M-NSG mice.
PDX肿瘤药效案例