博莱霉素（bleomycin，BLM）是一种肿瘤药物，对肺部存在毒性副作用。该药可以诱导DNA的断裂与氧化应激反应，从而引起实质炎症、上皮细胞损伤伴反应性增生、上皮-间充质转化、成纤维细胞活化并分化为肌成纤维细胞，以及基底膜和肺泡上皮损伤等症状。
Fig.1 Bleomycin induced pulmonary fibrosis in C57BL/6 (male, 10-12w) mice. (A) Body Weight. (B) Body Weight Change. (C) Survival Curve.
Fig2.Bleomycin induced pulmonary fibrosis in C57BL/6 (male, 10-12w) mice. (A) H&E and Masson stain. (B) Alveolar inflammation score. (C)Alveolar fibrosis score.
