同系移植瘤小鼠模型

同系移植瘤小鼠模型(Syngeneic models)是将同种背景来源的肿瘤细胞系接种至免疫健全的近交系小鼠(通常为 C57BL/6 或 BALB/c 小鼠)体内形成的移植瘤模型。
同系移植瘤小鼠模型免疫系统健全,可用干研究肿瘤的免疫治疗,常用于需要完整免疫系统的药效研究。

免疫健全小鼠

野生型小鼠
野生型小鼠

模型案例

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Fig. In vivo efficacy of anti-PD-1/CTLA-4 antibody drugs in inhibiting MC38 and CT26 colorectal cancer xenografts. 

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Fig. Mouse Lewis lung cancer pleural effusion model constructed by in situ injection of LLC-Luc cell line. a. Efficacy tumourigenic curve; b. Efficacy body weight curve; c. Survival rate of mice; d. Photographs of lungs, tumours, and pleural effusions in mice.


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Fig. In vivo efficacy of ADC drugs targeting NECTN4 to inhibit the progression of MC38-NECTIN4 homologous tumour cells (host is hPD-1 mice on C57BL6 background)


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Fig. Evaluation of antitumour efficacy in hTNFR2 humanised mice. a. Efficacy tumourigenic curve; b. Efficacy body weight curve.

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Fig. Evaluation of antitumour efficacy in hPD1/hCTLA4 humanised mice. a. Efficacy tumourigenic curve; b. Efficacy body weight curve.

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